GMP info

Regarding suitability of Eppendorf bioprocess equipment in GMP-regulated applications, please reach out to your Eppendorf sales representative.

Bioprocessing in Vaccine Development

At Eppendorf, our aim is to empower your upstream bioprocessing in vaccine development. We provide tools that help you accelerate process development by working in parallel, increasing turn-around time, and leveraging the full potential of bioprocess data. We support you in increasing cost-efficiency by intensifying bioprocesses and streamlining scale-up. You discover new ways for vaccine production. We deliver solutions to help bringing your bioprocess to the next level. So come and talk to us, we’re all ears.

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Bioprocess development for various vaccine types

Whether your vaccine is based on a virus, microorganism, or recombinant protein, we pay attention to your specific challenges and work together with you to solve them. Read more about upstream bioprocessing in the development of different vaccine types and find out how we can support you.

Bioreactor systems for bioprocess development for viral vector production

Viruses

Discover how our solutions can help you with your process development for viral vector production.

Bacteria

Discover how we can work together to take your production of whole pathogens, proteins, or plasmids through bacterial fermentation to new heights.

Recombinant proteins made in cells

We aim to help you bring your cell culture bioprocess to the next level. Find out more!

Our bioprocess solutions for vaccine development

We are not about one-size-fits-all solutions – instead we focus on empowering your business with tailored bioprocess solutions.

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Discover our bioprocess portfolio

Scalable bioprocess systems‌

Single-use bioreactors‌

Cell culture in perfusion‌

Cultivation of adherent cells‌

The value of bioreactors in vaccine development

Vaccines are critical to both human and animal health. They are becoming an ever more vital tool in the fight against current and future diseases. To meet the growing global demand for new vaccines, it is important to be able to produce them in an efficient and cost-effective manner. Find out, how cell culture in bioreactors offers a standardized, scalable, and cost-effective way for developing vaccines and how our bioprocess solutions can support you with your specific challenge.

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Webinar: Stirred tank bioreactors in vaccine development

The use of cell culture in bioreactors offers a standardized, scalable, and cost-effective procedure for developing vaccines. Learn, how suspension cells were efficiently cultivated in bioreactors to produce AAV particles and COVID-19 spike-proteins in suspension culture.

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Webinar announcement: AAV production in bioreactors

Process development

The purpose of upstream bioprocess development is to reduce the overall manufacturing cost of vaccine development while maximizing the quantity and quality of the desired final product. Various cultivation parameters, such as the temperature, pH , DO , shear force, and nutrient supply can affect cell growth and protein expression levels. Thus, it is essential to evaluate each of these conditions and their interactions to determine the most effective conditions for your bioprocess.

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Learn more about how the Eppendorf solutions help you saving time in bioprocess development.

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Bioprocess scale-up

Bioprocess insight gained at small-scale can help to ensure a high level of success in your large-scale processes. Once the ideal conditions have been achieved, bioreactors can be used to effectively scale-up your culture from benchtop to pilot and industrial scales. Several scale-up strategies exist to ensure maximum efficiency and product quality is maintained.

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Learn more about scale-up strategies and how the Eppendorf bioprocess equipment can help streamlining scale-up.

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Process intensification

Process intensification, a methodology for reducing equipment, energy consumption, and waste generation while achieving higher quality products, can make a substantial contribution to further increasing process productivity and lowering production costs. One way to optimize your bioprocessing is fine-tuning the control of your bioprocess through Process Analytic Technology (PAT) which can help to improve reproducibility, reduce batch-to-batch variation, and increase yields and product quality. Another important consideration when intensifying the rate or increasing the yield is which operation mode to use for your bioprocess. A variety of strategies including batch, fed-batch, and continuous cultures exist to help you optimize batch quality and yield.

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Learn more about how to reduce batch-to-batch variability and increase yield.

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How our customers use our products

The real experts are our customers. Meet some of them and find out what their work is all about.

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Vaxcyte^®: Scaling up cell-free expression

Read, how scientists at the University of Maryland School of Medicine and Vaxcyte^® , Inc. scaled-up the cell-free expression of a vaccine candidate in Eppendorf bioreactor systems.

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Hunan Cancer Hospital: Perfusion cultivation of Vero cells

Read, how researchers at the Hunan Cancer Hospital, the Hunan Clinical Medical Research Center of Gastrointestinal Tumor, and Hefei University set up perfusion cultivation of Vero cells on microcarriers using the BioFlo^® 320 bioreactor control system equipped with Cell-Lift impeller and decanter column.

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Worcester Polytechnic Institute: Vero cell culture on Fibra-Cel^® Disks

Scientists at the Worcester Polytechnic Institute found bioreactors with a packed-bed made of Fibra-Cel^® Disks to be an excellent choice for culturing Vero cells.

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Bioprocessing in Vaccine Development